The sweet taste receptor is a heterodimer composed of T1R2 and T1R3 subunits that together detect sugars and sweeteners.

Sweetness perception relies on the T1R2 and T1R3 proteins pairing up to form a receptor. This duo binds various sweet molecules, from natural sugars like glucose to artificial sweeteners. Alone, T1R3 cannot signal sweetness effectively, but combined with T1R2, it creates the key gateway for sweet taste detection on the tongue.